Research
Our Research
We contribute to arrhythmia research through the Alfred Hospital, the Baker Heart Institute, and the University of Melbourne. We are dedicated to improving the understanding and treatment of heart rhythm disorders.
Through strong clinical and research ties between the Alfred Hospital, The Royal Melbourne Hospital, and St Bartholomew’s Hospital, London, we offer the opportunity for you to be involved in one of our clinical studies during the course of your treatment.
If you are eligible and willing, a member of our research team would be delighted to discuss your involvement in more detail.
Publications
- 2023 Publications
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- Effect of Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The CAPLA Randomized Clinical Trial.
Kistler PM, Chieng D, Sugumar H, Ling LH, Segan L, Azzopardi S, Al-Kaisey A, Parameswaran R, Anderson RD, Hawson J, Prabhu S, Voskoboinik A, Wong G, Morton JB, Pathik B, McLellan AJ, Lee G, Wong M, Finch S, Pathak RK, Raja DC, Sterns L, Ginks M, Reid CM, Sanders P, Kalman JM.
JAMA 2023
- Effect of Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The CAPLA Randomized Clinical Trial.
- 2022 Publications
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- Higher power short duration vs. lower power longer duration posterior wall ablation for atrial fibrillation and oesophageal injury outcomes: a prospective multi-centre randomized controlled study (Hi-Lo HEAT trial).
Chieng D, Segan L, Sugumar H, Al-Kaisey A, Hawson J, Moore BM, Nam MCY, Voskoboinik A, Prabhu S, Ling LH, Ng JF, Brown G, Lee G, Morton J, Debinski H, Kalman JM, Kistler PM.
Europace 2022 - The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank.
Chieng D, Canovas R, Segan L, Sugumar H, Voskoboinik A, Prabhu S, Ling LH, Lee G, Morton JB, Kaye DM, Kalman JM, Kistler PM.
Eur J Prev Cardiol 2022 - Impact of CPAP on the Atrial Fibrillation Substrate in Obstructive Sleep Apnea: The SLEEP-AF Study.
Nalliah CJ, Wong GR, Lee G, Voskoboinik A, Kee K, Goldin J, Watts T, Linz D, Parameswaran R, Sugumar H, Prabhu S, McLellan A, Ling LH, Joseph SA, Morton JB, Kistler P, Sanders P, Kalman JM.
JACC Clin Electrophysiol 2022 - Sex-Related Differences in Atrial Remodeling in Patients With Atrial Fibrillation: Relationship to Ablation Outcomes.
Wong GR, Nalliah CJ, Lee G, Voskoboinik A, Chieng D, Prabhu S, Parameswaran R, Sugumar H, Al-Kaisey A, McLellan A, Ling LH, Sanders P, Kistler PM, Kalman JM.
Circ Arrhythm Electrophysiol 2022 - Catheter ablation for persistent atrial fibrillation: A multicenter randomized trial of pulmonary vein isolation (PVI) versus PVI with posterior left atrial wall isolation (PWI) – The CAPLA study.
Chieng D, Sugumar H, Ling LH, Segan L, Azzopardi S, Prabhu S, Al-Kaisey A, Voskoboinik A, Parameswaran R, Morton JB, Pathik B, McLellan AJ, Lee G, Wong M, Finch S, Pathak RK, Raja DC, Sanders P, Sterns L, Ginks M, Reid CM, Kalman JM, Kistler PM.
Am Heart J. 2022
- Higher power short duration vs. lower power longer duration posterior wall ablation for atrial fibrillation and oesophageal injury outcomes: a prospective multi-centre randomized controlled study (Hi-Lo HEAT trial).
- 2021 Publications
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- A prospective evaluation of the impact of individual RF applications for slow pathway ablation for AVNRT: markers of acute success.
Sugumar H, Chieng D, Prabhu S, Voskoboinik A, Anderson RD, Al-Kaisey A, Lee G, McLellan AJ, Morton JB, Taylor AJ, Ling LH, Kalman JM, Kistler PM.
J Cardiovasc Electrophysiol 2021 - A prospective study using invasive haemodynamic measurements following catheter ablation for AF and early HFpEF: STALL AF‐HFpEF.
Sugumar H, Nanayakkara S, Vizi D, Wright L, Chieng D, Leet A, Mariani JA, Voskoboinik A, Prabhu S, Taylor AJ, Kalman J, Kistler PM, Kaye DM, Ling LH.
Eur J Heart Fail 2021
- A prospective evaluation of the impact of individual RF applications for slow pathway ablation for AVNRT: markers of acute success.
- 2020 Publications
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- DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure.
Duffy C, Bain C, Cairo SA, Hogan C, Geldard P, Larobina M, Lin E, Tutungi E, Miles LF.
J Cardiothorac Vasc Anesth 2020 - Multipolar mapping with the high-density grid catheter compared with conventional point-by-point mapping to guide catheter ablation for focal arrhythmias.
Chieng D, Lahiri A, Sugumar H, Al-Kaisey A, Parameswaran R, Anderson RD, Prabhu S, Ling LH, Morton JB, McLellan AJ, Lee G, Kalman JM, McGavigan AD, Kistler PM.
J Cardiovasc Electrophysiol 2020 - Arrhythmia recurrence is more common in females undergoing multiple catheter ablation procedures for persistent atrial fibrillation: Time to close the gender gap.
Sugumar H, Nanayakkara S, Chieng D, Wong GR, Parameswaran R, Anderson RD, Al-Kaisey A, Nalliah CJ, Azzopardi S, Prabhu S, Voskoboinik A, Lee G, McLellan AJ, Ling LH, Morton JB, Kalman JM, Kistler PM.
Cardiol Clin 2019
- DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure.
- 2019 Publications
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- Atrial Remodeling Following Catheter Ablation for Atrial Fibrillation-Mediated Cardiomyopathy: Long-Term Follow-Up of CAMERA-MRI Study.
Sugumar H, Prabhu S, Voskoboinik A, Young S, Gutman SJ, Wong GR, Parameswaran R, Nalliah CJ, Lee G, McLellan AJ, Taylor AJ, Ling LH, Kalman JM, Kistler PM.
JACC Clin Electrophysiol 2019 - Pathophysiology of Atrial Fibrillation and Heart Failure: Dangerous Interactions.
Sugumar H, Nanayakkara S, Prabhu S, Voskoboinik A, Kaye DM, Ling LH, Kistler PM.
Cardiol Clin 2019 - Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping.
Voskoboinik A, Wong G, Lee G, Nalliah C, Hawson J, Prabhu S, Sugumar H, Ling LH, McLellan A, Morton J, Kalman JM, Kistler PM.
Heart Rhythm 2019 Feb - Cardioversion of atrial fibrillation in obese patients: Results from the Cardioversion-BMI randomized controlled trial.
Voskoboinik A, Moskovitch J, Plunkett G, Bloom J, Wong G, Nalliah C, Prabhu S, Sugumar H, Paramasweran R, McLellan A, Ling LH, Goh CY, Noaman S, Fernando H, Wong M, Taylor AJ, Kalman JM, Kistler PM
J Cardiovasc Electrophysiol 2019
- Atrial Remodeling Following Catheter Ablation for Atrial Fibrillation-Mediated Cardiomyopathy: Long-Term Follow-Up of CAMERA-MRI Study.
- 2018 Publications
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- Regular Alcohol Consumption Is Associated With Impaired Atrial Mechanical Function in the Atrial Fibrillation Population: A Cross-Sectional MRI-Based Study.
Voskoboinik A, Costello BT, Kalman E, Prabhu S, Sugumar H, Wong G, Nalliah C, Ling LH, McLellan A, Hettige T, Springer F, La Gerche A, Kalman JM, Taylor AJ, Kistler PM.
JACC Clin Electrophysiol 2018 - Regression of Diffuse Ventricular Fibrosis Following Restoration of Sinus Rhythm With Catheter Ablation in Patients With Atrial Fibrillation and Systolic Dysfunction: A Substudy of the CAMERA MRI Trial.
Prabhu S, Costello BT, Taylor AJ, Gutman SJ, Voskoboinik A, McLellan AJA, Peck KY, Sugumar H, Iles L, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Lee G, Mariani J, Kaye DM, Ling LH, Kalman JM, Kistler PM.
JACC Clin Electrophysiol 2018 - Pulmonary vein activity does not predict the outcome of catheter ablation for persistent atrial fibrillation: A long-term multicenter prospective study.
Prabhu S, Kalla M, Peck KY, Voskoboinik A, McLellan AJA, Pathik B, Nalliah CJ, Wong GR, Sugumar H, Azzopardi SM, Lee G, Ling LH, Kalman JM, Kistler PM.
Heart Rhythm 2018 - Biatrial Electrical and Structural Atrial Changes in Heart Failure: Electroanatomic Mapping in Persistent Atrial Fibrillation in Humans.
Prabhu S, Voskoboinik A, McLellan AJA, Peck KY, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Lee G, Mariani J, Ling LH, Taylor AJ, Kalman JM, Kistler PM.
JACC Clin Electrophysiol 2018
- Regular Alcohol Consumption Is Associated With Impaired Atrial Mechanical Function in the Atrial Fibrillation Population: A Cross-Sectional MRI-Based Study.
- 2017 Publications
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- Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Systolic Dysfunction: The CAMERA-MRI Study.
Prabhu S, Taylor AJ, Costello BT, Kaye DM, McLellan AJA, Voskoboinik A, Sugumar H, Lockwood SM, Stokes MB, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Gutman SJ, Lee G, Layland J, Mariani JA, Ling LH, Kalman JM, Kistler PM.
J Am Coll Cardiol 2017 - A comparison of the electrophysiologic and electroanatomic characteristics between the right and left atrium in persistent atrial fibrillation: Is the right atrium a window into the left?
Prabhu S, Voskoboinik A, McLellan AJA, Peck KY, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Lee G, Mariani J, Ling LH, Taylor AJ, Kalman JM, Kistler PM.
J Cardiovasc Electrophysiol 2017 - The role of adenosine challenge in catheter ablation for atrial fibrillation: A systematic review and meta-analysis.
McLellan AJA, Kumar S, Smith C, Ling LH, Prabhu S, Kalman JM, Kistler PM.
Int J Cardiol 2017 - Alcohol and Atrial Fibrillation: A Sobering Review.
Voskoboinik A, Prabhu S, Ling LH, Kalman JM, Kistler PM.
J Am Coll Cardiol 2017 - Determining the Optimal Dose of Adenosine for Unmasking Dormant Pulmonary Vein Conduction Following Atrial Fibrillation Ablation: Electrophysiological and Hemodynamic Assessment. DORMANT-AF Study.
Prabhu S, Mackin V, McLellan AJ, Phan T, McGlade D, Ling LH, Peck KY, Voskoboinik A, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Lee G, Mariani J, Taylor AJ, Kalman JM, Kistler PM.
J Cardiovasc Electrophysiol 2017
- Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Systolic Dysfunction: The CAMERA-MRI Study.
- 2016 Publications
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- Catheter ablation of atrial fibrillation in patients with heart failure: impact of maintaining sinus rhythm on heart failure status and long-term rates of stroke and death.
Ullah W, Ling LH, Prabhu S, Lee G, Kistler P, Finlay MC, Earley MJ, Sporton S, Bashir Y, Betts TR, Rajappan K, Thomas G, Duncan E, Staniforth A, Mann I, Chow A, Lambiase P, Schilling RJ, Hunter RJ.
Europace 2016 - The Impact of Known Heart Disease on Long-Term Outcomes of Catheter Ablation in Patients with Atrial Fibrillation and Left Ventricular Systolic Dysfunction: A Multicenter International Study.
Prabhu S, Ling LH, Ullah W, Hunter RJ, Schilling RJ, McLellan AJ, Earley MJ, Sporton SC, Voskoboinik A, Blusztein D, Mariani JA, Lee G, Taylor AJ, Kalman JM, Kistler PM.
J Cardiovasc Electrophysiol. 2016 - Comorbidity of atrial fibrillation and heart failure.
Ling LH, Kistler PM, Kalman JM, Schilling RJ, Hunter RJ.
Nat Rev Cardiol 2016
- Catheter ablation of atrial fibrillation in patients with heart failure: impact of maintaining sinus rhythm on heart failure status and long-term rates of stroke and death.
- 2015 Publications
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- Impact of Catheter Contact Force on Human Left Atrial Electrogram Characteristics in Sinus Rhythm and Atrial Fibrillation.
Ullah W, Hunter RJ, Baker V, Ling LH, Dhinoja MB, Sporton S, Earley MJ, Schilling RJ.
Circ Arrhythm Electrophysiol 2015 - A minimal or maximal ablation strategy to achieve pulmonary vein isolation for paroxysmal atrial fibrillation: a prospective multi-centre randomized controlled trial (the Minimax study).
McLellan AJ, Ling LH, Azzopardi S, Lee GA, Lee G, Kumar S, Wong MC, Walters TE, Lee JM, Looi KL, Halloran K, Stiles MK, Lever NA, Fynn SP, Heck PM, Sanders P, Morton JB, Kalman JM, Kistler PM.
Eur Heart J 2015 - Increased prothrombotic profile in the left atrial appendage of atrial fibrillation patients.
Breitenstein A, Glanzmann M, Falk V, Maisano F, Stämpfli SF, Holy EW, Finlay M, Ling LH, Schilling RJ, Lüscher TF, Steffel J, Camici GG.
Int J Cardiol 2015 - The transesophageal echo probe may contribute to esophageal injury after catheter ablation for paroxysmal atrial fibrillation under general anesthesia: a preliminary observation.
Kumar S, Brown G, Sutherland F, Morgan J, Andrews D, Ling LH, McLELLAN AJ, Lee G, Robinson T, Heck P, Halloran K, Morton J, Kistler P, Kalman JM, Sparks PB.
J Cardiovasc Electrophysiol 2015
- Impact of Catheter Contact Force on Human Left Atrial Electrogram Characteristics in Sinus Rhythm and Atrial Fibrillation.
- 2014 Publications
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- Diffuse ventricular fibrosis measured by T₁ mapping on cardiac MRI predicts success of catheter ablation for atrial fibrillation.
McLellan AJ, Ling LH, Azzopardi S, Ellims AH, Iles LM, Sellenger MA, Morton JB, Kalman JM, Taylor AJ, Kistler PM.
Circ Arrhythm Electrophysiol 2014 - Magnetic resonance post-contrast T1 mapping in the human atrium: validation and impact on clinical outcome after catheter ablation for atrial fibrillation.
Ling LH, McLellan AJ, Taylor AJ, Iles LM, Ellims AH, Kumar S, Teh A, Lee G, Wong MC, Azzopardi S, Sellenger MA, Morton JB, Kalman JM, Kistler PM.
Heart Rhythm 2014 - A comprehensive evaluation of myocardial fibrosis in hypertrophic cardiomyopathy with cardiac magnetic resonance imaging: linking genotype with fibrotic phenotype.
Ellims AH, Iles LM, Ling LH, Chong B, Macciocca I, Slavin GS, Hare JL, Kaye DM, Marasco SF, McLean CA, James PA, du Sart D, Taylor AJ.
Eur Heart J Cardiovasc Imaging 2014 - Evaluating the utility of circulating biomarkers of collagen synthesis in hypertrophic cardiomyopathy.
Ellims AH, Taylor AJ, Mariani JA, Ling LH, Iles LM, Maeder MT, Kaye DM.
Circ Heart Fail 2014 - Pulmonary vein isolation: the impact of pulmonary venous anatomy on long-term outcome of catheter ablation for paroxysmal atrial fibrillation.
McLellan AJ, Ling LH, Ruggiero D, Wong MC, Walters TE, Nisbet A, Shetty AK, Azzopardi S, Taylor AJ, Morton JB, Kalman JM, Kistler PM.
Heart Rhythm 2014 - Validation of conventional fluoroscopic and ECG criteria for right ventricular pacemaker lead position using cardiac computed tomography.
Pang BJ, Joshi SB, Lui EH, Tacey MA, Ling LH, Alison J, Seneviratne SK, Cameron JD, Mond HG.
Pacing Clin Electrophysiol 2014
- Diffuse ventricular fibrosis measured by T₁ mapping on cardiac MRI predicts success of catheter ablation for atrial fibrillation.
- 2013 Publications
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- Associations between fibrocytes and postcontrast myocardial T1 times in hypertrophic cardiomyopathy.
Fang L, Beale A, Ellims AH, Moore XL, Ling LH, Taylor AJ, Chin-Dusting J, Dart AM.
J Am Heart Assoc 2013 Oct\ - Diffuse ventricular fibrosis is a late outcome of tachycardia-mediated cardiomyopathy after successful ablation.
Ling LH, Kalman JM, Ellims AH, Iles LM, Medi C, Sherratt C, Kaye DM, Hare JL, Kistler PM, Taylor AJ.
Circ Arrhythm Electrophysiol 2013 - Sinus rhythm restores ventricular function in patients with cardiomyopathy and no late gadolinium enhancement on cardiac magnetic resonance imaging who undergo catheter ablation for atrial fibrillation.
Ling LH, Taylor AJ, Ellims AH, Iles LM, McLellan AJ, Lee G, Kumar S, Lee G, Teh A, Medi C, Kaye DM, Kalman JM, Kistler PM.
Heart Rhythm 2013 - Predictive value of impedance changes for real-time contact force measurements during catheter ablation of atrial arrhythmias in humans.
Kumar S, Haqqani HM, Chan M, Lee J, Yudi M, Wong MC, Morton JB, Ling LH, Robinson T, Heck PM, Kelland NF, Halloran K, Spence SJ, Kistler PM, Kalman JM.
Heart Rhythm 2013 - Left septal atrial tachycardias: electrocardiographic and electrophysiologic characterization of a paraseptal focus.
Wong MC, Kalman JM, Ling LH, Medi C, Teh A, Lee G, Kumar S, Morton JB, Kistler PM.
J Cardiovasc Electrophysiol 2013
- Associations between fibrocytes and postcontrast myocardial T1 times in hypertrophic cardiomyopathy.
- 2012 Publications
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- Diffuse ventricular fibrosis in atrial fibrillation: noninvasive evaluation and relationships with aging and systolic dysfunction.
Ling LH, Kistler PM, Ellims AH, Iles LM, Lee G, Hughes GL, Kalman JM, Kaye DM, Taylor AJ.
J Am Coll Cardiol 2012 - Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction.
Ellims AH, Iles LM, Ling LH, Hare JL, Kaye DM, Taylor AJ.
J Cardiovasc Magn Reson 2012 - Irregular rhythm adversely influences calcium handling in ventricular myocardium: implications for the interaction between heart failure and atrial fibrillation.
Ling LH, Khammy O, Byrne M, Amirahmadi F, Foster A, Li G, Zhang L, dos Remedios C, Chen C, Kaye DM.
Circ Heart Fail 2012 - Depression and 5-year mortality in patients with acute myocardial infarction: analysis of the IDACC database.
Wheeler A, Beltrame J, Tucker G, Air T, Ling LH, Schrader G.
Aust N Z J Psychiatry 2012 - Esophageal hematoma after atrial fibrillation ablation: incidence, clinical features, and sequelae of esophageal injury of a different sort.
Kumar S, Ling LH, Halloran K, Morton JB, Spence SJ, Joseph S, Kistler PM, Sparks PB, Kalman JM.
Circ Arrhythm Electrophysiol 2012 - Supraventricular arrhythmias late after orthotopic cardiac transplantation: electrocardiographic and electrophysiological characterization and radiofrequency ablation.
Elsik M, Teh A, Ling LH, Virdee M, Parameshwar J, Fynn SP, Kistler PM.
Europace 2012 - Atrial electrical and structural remodelling associated with longstanding pulmonary hypertension and right ventricular hypertrophy in humans.
Medi C, Kalman JM, Ling LH, Teh AW, Lee G, Lee G, Spence SJ, Kaye DM, Kistler PM.
J Cardiovasc Electrophysiol 2012
- Diffuse ventricular fibrosis in atrial fibrillation: noninvasive evaluation and relationships with aging and systolic dysfunction.
- 2011 and Prior Publications
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- Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline.
Ling LH, Chik W, Averbuj P, Pati PK, Sverdlov AL, Ngo DT, Morris RG, Sallustio BC, Horowitz JD.
Ther Drug Monit 2011 - Multielectrode catheter ablation: linear ablation made easy?
Ling LH, Kistler PM.
J Cardiovasc Electrophysiol. 2011 - Dissociated pulmonary vein potentials following antral pulmonary vein isolation for atrial fibrillation: impact on long-term outcome.
Lee G, Kalman JM, Vohra JK, Teh A, Medi C, Ling LH, Kistler PM.
Heart 2011 - Poisoning with the recreational drug paramethoxyamphetamine (“death”).
Ling LH, Marchant C, Buckley NA, Prior M, Irvine RJ.
Med J Aust 2001
- Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline.