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Research

Our Research

The Heart Rhythm Clinic conducts arrhythmia research through the Alfred Hospital, the Baker Heart Institute, and the University of Melbourne. We are dedicated to improving the understanding and treatment of heart rhythm disorders.

Through strong clinical and research ties between the Alfred Hospital, The Royal Melbourne Hospital, and St Bartholomew’s Hospital, London, we offer the opportunity for you to be involved in one of our clinical studies during the course of your treatment.

If you are eligible and willing, a member of our research team would be delighted to discuss your involvement in more detail.

 


Publications

2019 Publications
2018 Publications
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2017 Publications
  • Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Systolic Dysfunction: The CAMERA-MRI Study.
    Prabhu S, Taylor AJ, Costello BT, Kaye DM, McLellan AJA, Voskoboinik A, Sugumar H, Lockwood SM, Stokes MB, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Gutman SJ, Lee G, Layland J, Mariani JA, Ling LH, Kalman JM, Kistler PM.
    J Am Coll Cardiol 2017
  • A comparison of the electrophysiologic and electroanatomic characteristics between the right and left atrium in persistent atrial fibrillation: Is the right atrium a window into the left?
    Prabhu S, Voskoboinik A, McLellan AJA, Peck KY, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Lee G, Mariani J, Ling LH, Taylor AJ, Kalman JM, Kistler PM.
    J Cardiovasc Electrophysiol 2017
  • The role of adenosine challenge in catheter ablation for atrial fibrillation: A systematic review and meta-analysis.
    McLellan AJA, Kumar S, Smith C, Ling LH, Prabhu S, Kalman JM, Kistler PM.
    Int J Cardiol 2017
  • Alcohol and Atrial Fibrillation: A Sobering Review.
    Voskoboinik A, Prabhu S, Ling LH, Kalman JM, Kistler PM.
    J Am Coll Cardiol 2017
  • Determining the Optimal Dose of Adenosine for Unmasking Dormant Pulmonary Vein Conduction Following Atrial Fibrillation Ablation: Electrophysiological and Hemodynamic Assessment. DORMANT-AF Study.
    Prabhu S, Mackin V, McLellan AJ, Phan T, McGlade D, Ling LH, Peck KY, Voskoboinik A, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Lee G, Mariani J, Taylor AJ, Kalman JM, Kistler PM.
    J Cardiovasc Electrophysiol 2017
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2016 Publications
  • Catheter ablation of atrial fibrillation in patients with heart failure: impact of maintaining sinus rhythm on heart failure status and long-term rates of stroke and death.
    Ullah W, Ling LH, Prabhu S, Lee G, Kistler P, Finlay MC, Earley MJ, Sporton S, Bashir Y, Betts TR, Rajappan K, Thomas G, Duncan E, Staniforth A, Mann I, Chow A, Lambiase P, Schilling RJ, Hunter RJ.
    Europace 2016
  • The Impact of Known Heart Disease on Long-Term Outcomes of Catheter Ablation in Patients with Atrial Fibrillation and Left Ventricular Systolic Dysfunction: A Multicenter International Study.
    Prabhu S, Ling LH, Ullah W, Hunter RJ, Schilling RJ, McLellan AJ, Earley MJ, Sporton SC, Voskoboinik A, Blusztein D, Mariani JA, Lee G, Taylor AJ, Kalman JM, Kistler PM.
    J Cardiovasc Electrophysiol. 2016
  • Comorbidity of atrial fibrillation and heart failure.
    Ling LH, Kistler PM, Kalman JM, Schilling RJ, Hunter RJ.
    Nat Rev Cardiol 2016
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2015 Publications
  • Impact of Catheter Contact Force on Human Left Atrial Electrogram Characteristics in Sinus Rhythm and Atrial Fibrillation.
    Ullah W, Hunter RJ, Baker V, Ling LH, Dhinoja MB, Sporton S, Earley MJ, Schilling RJ.
    Circ Arrhythm Electrophysiol 2015
  • A minimal or maximal ablation strategy to achieve pulmonary vein isolation for paroxysmal atrial fibrillation: a prospective multi-centre randomized controlled trial (the Minimax study).
    McLellan AJ, Ling LH, Azzopardi S, Lee GA, Lee G, Kumar S, Wong MC, Walters TE, Lee JM, Looi KL, Halloran K, Stiles MK, Lever NA, Fynn SP, Heck PM, Sanders P, Morton JB, Kalman JM, Kistler PM.
    Eur Heart J 2015
  • Increased prothrombotic profile in the left atrial appendage of atrial fibrillation patients.
    Breitenstein A, Glanzmann M, Falk V, Maisano F, Stämpfli SF, Holy EW, Finlay M, Ling LH, Schilling RJ, Lüscher TF, Steffel J, Camici GG.
    Int J Cardiol 2015
  • The transesophageal echo probe may contribute to esophageal injury after catheter ablation for paroxysmal atrial fibrillation under general anesthesia: a preliminary observation.
    Kumar S, Brown G, Sutherland F, Morgan J, Andrews D, Ling LH, McLELLAN AJ, Lee G, Robinson T, Heck P, Halloran K, Morton J, Kistler P, Kalman JM, Sparks PB.
    J Cardiovasc Electrophysiol 2015
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2014 Publications
  • Diffuse ventricular fibrosis measured by T₁ mapping on cardiac MRI predicts success of catheter ablation for atrial fibrillation.
    McLellan AJ, Ling LH, Azzopardi S, Ellims AH, Iles LM, Sellenger MA, Morton JB, Kalman JM, Taylor AJ, Kistler PM.
    Circ Arrhythm Electrophysiol 2014
  • Magnetic resonance post-contrast T1 mapping in the human atrium: validation and impact on clinical outcome after catheter ablation for atrial fibrillation.
    Ling LH, McLellan AJ, Taylor AJ, Iles LM, Ellims AH, Kumar S, Teh A, Lee G, Wong MC, Azzopardi S, Sellenger MA, Morton JB, Kalman JM, Kistler PM.
    Heart Rhythm 2014
  • A comprehensive evaluation of myocardial fibrosis in hypertrophic cardiomyopathy with cardiac magnetic resonance imaging: linking genotype with fibrotic phenotype.
    Ellims AH, Iles LM, Ling LH, Chong B, Macciocca I, Slavin GS, Hare JL, Kaye DM, Marasco SF, McLean CA, James PA, du Sart D, Taylor AJ.
    Eur Heart J Cardiovasc Imaging 2014
  • Evaluating the utility of circulating biomarkers of collagen synthesis in hypertrophic cardiomyopathy.
    Ellims AH, Taylor AJ, Mariani JA, Ling LH, Iles LM, Maeder MT, Kaye DM.
    Circ Heart Fail 2014
  • Pulmonary vein isolation: the impact of pulmonary venous anatomy on long-term outcome of catheter ablation for paroxysmal atrial fibrillation.
    McLellan AJ, Ling LH, Ruggiero D, Wong MC, Walters TE, Nisbet A, Shetty AK, Azzopardi S, Taylor AJ, Morton JB, Kalman JM, Kistler PM.
    Heart Rhythm 2014
  • Validation of conventional fluoroscopic and ECG criteria for right ventricular pacemaker lead position using cardiac computed tomography.
    Pang BJ, Joshi SB, Lui EH, Tacey MA, Ling LH, Alison J, Seneviratne SK, Cameron JD, Mond HG.
    Pacing Clin Electrophysiol 2014
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2013 Publications
  • Associations between fibrocytes and postcontrast myocardial T1 times in hypertrophic cardiomyopathy.
    Fang L, Beale A, Ellims AH, Moore XL, Ling LH, Taylor AJ, Chin-Dusting J, Dart AM.
    J Am Heart Assoc 2013 Oct\
  • Diffuse ventricular fibrosis is a late outcome of tachycardia-mediated cardiomyopathy after successful ablation.
    Ling LH, Kalman JM, Ellims AH, Iles LM, Medi C, Sherratt C, Kaye DM, Hare JL, Kistler PM, Taylor AJ.
    Circ Arrhythm Electrophysiol 2013
  • Sinus rhythm restores ventricular function in patients with cardiomyopathy and no late gadolinium enhancement on cardiac magnetic resonance imaging who undergo catheter ablation for atrial fibrillation.
    Ling LH, Taylor AJ, Ellims AH, Iles LM, McLellan AJ, Lee G, Kumar S, Lee G, Teh A, Medi C, Kaye DM, Kalman JM, Kistler PM.
    Heart Rhythm 2013
  • Predictive value of impedance changes for real-time contact force measurements during catheter ablation of atrial arrhythmias in humans.
    Kumar S, Haqqani HM, Chan M, Lee J, Yudi M, Wong MC, Morton JB, Ling LH, Robinson T, Heck PM, Kelland NF, Halloran K, Spence SJ, Kistler PM, Kalman JM.
    Heart Rhythm 2013
  • Left septal atrial tachycardias: electrocardiographic and electrophysiologic characterization of a paraseptal focus.
    Wong MC, Kalman JM, Ling LH, Medi C, Teh A, Lee G, Kumar S, Morton JB, Kistler PM.
    J Cardiovasc Electrophysiol 2013
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2012 Publications
  • Diffuse ventricular fibrosis in atrial fibrillation: noninvasive evaluation and relationships with aging and systolic dysfunction.
    Ling LH, Kistler PM, Ellims AH, Iles LM, Lee G, Hughes GL, Kalman JM, Kaye DM, Taylor AJ.
    J Am Coll Cardiol 2012
  • Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by cardiovascular magnetic resonance, and is associated with left ventricular diastolic dysfunction.
    Ellims AH, Iles LM, Ling LH, Hare JL, Kaye DM, Taylor AJ.
    J Cardiovasc Magn Reson 2012
  • Irregular rhythm adversely influences calcium handling in ventricular myocardium: implications for the interaction between heart failure and atrial fibrillation.
    Ling LH, Khammy O, Byrne M, Amirahmadi F, Foster A, Li G, Zhang L, dos Remedios C, Chen C, Kaye DM.
    Circ Heart Fail 2012
  • Depression and 5-year mortality in patients with acute myocardial infarction: analysis of the IDACC database.
    Wheeler A, Beltrame J, Tucker G, Air T, Ling LH, Schrader G.
    Aust N Z J Psychiatry 2012
  • Esophageal hematoma after atrial fibrillation ablation: incidence, clinical features, and sequelae of esophageal injury of a different sort.
    Kumar S, Ling LH, Halloran K, Morton JB, Spence SJ, Joseph S, Kistler PM, Sparks PB, Kalman JM.
    Circ Arrhythm Electrophysiol 2012
  • Supraventricular arrhythmias late after orthotopic cardiac transplantation: electrocardiographic and electrophysiological characterization and radiofrequency ablation.
    Elsik M, Teh A, Ling LH, Virdee M, Parameshwar J, Fynn SP, Kistler PM.
    Europace 2012
  • Atrial electrical and structural remodelling associated with longstanding pulmonary hypertension and right ventricular hypertrophy in humans.
    Medi C, Kalman JM, Ling LH, Teh AW, Lee G, Lee G, Spence SJ, Kaye DM, Kistler PM.
    J Cardiovasc Electrophysiol 2012
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2011 and Prior Publications
  • Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline.
    Ling LH, Chik W, Averbuj P, Pati PK, Sverdlov AL, Ngo DT, Morris RG, Sallustio BC, Horowitz JD.
    Ther Drug Monit 2011
  • Multielectrode catheter ablation: linear ablation made easy?
    Ling LH, Kistler PM.
    J Cardiovasc Electrophysiol. 2011
  • Dissociated pulmonary vein potentials following antral pulmonary vein isolation for atrial fibrillation: impact on long-term outcome.
    Lee G, Kalman JM, Vohra JK, Teh A, Medi C, Ling LH, Kistler PM.
    Heart 2011
  • Poisoning with the recreational drug paramethoxyamphetamine (“death”).
    Ling LH, Marchant C, Buckley NA, Prior M, Irvine RJ.
    Med J Aust 2001
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